_id
695fba25c2e91020a7bd430a
Ticker
0JDI.LSE
Name
Ionis Pharmaceuticals, Inc.
Exchange
LSE
Address
2855 Gazelle Court, Carlsbad, CA, United States, 92010
Country
UK
Sector
Industry
Currency
USD
Website
https://www.ionis.com
Description
Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); Donidalorsen for patients with hereditary angioedema; and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 that has completed Phase 2 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.
Last Close
81.78
Volume
51
Current Price
83.7252
Last Updated
2026-01-08T14:07:33.585Z
Ipo Date
-
Market Cap
1098492313600
Next Dividend Date
-
Dividend Frequency
-
Dividend Rate
-
Dividend Yield
0
Sentiment
-
Sentiment Sources
0
Current Quarter
2025-10-28
Revenue
156719000
Cost Of Revenue
2338000
Gross Profit
154381000
Operating Expenses
314563000
Operating Income
-160182000
Interest Expense
22164000
Pretax Income
-128393000
Net Income
-128606000
Eps
-0.7999975117879048
Dividends Per Share
-
Shares Outstanding
137572000
Income Tax Expense
213000
EBITDA
-94378000
Operating Margin
-102.20968740229328
Total Other Income Expense Net
31789000
Cash
338341000
Short Term Investments
1901830000
Receivables
25000000
Inventories
10470000
Total Current Assets
2518993000
Property Plant Equipment
348110000
Total Assets
3033091000
Payables
14326000
Short Term Debt
630911000
Long Term Debt
-
Total Liabilities
2415124000
Equity
617967000
Bs_currency_symbol
-
Depreciation
11851000
Change In Working Capital
69658000
Cash From Operations
-131437000
Capital Expenditures
3306000
Cash From Investing
91338000
Cash From Financing
81218000
Net Change In Cash
41037000
Cf_currency_symbol
-
PE
-
PB
21.78028228303453
ROE
-20.81114363711978
ROA
-4.240096983572204
FCF
-134743000
Fcf Percent
-0.8597745008582239
Piotroski FScore
0
Health Score
8
Deep Value Investing Score
2
Defensive Investing Score
5.5
Dividend Investing Score
1.5
Economic Moat Investing Score
4.3
Garp Investing Score
1
Growth Investing Score
1.5
Momentum Investing Score
4.5
Net Net Investing Score
1
Quality Investing Score
1.5
Value Investing Score
2
Quarters > 0 > quarter
2025-10-28
Quarters > 0 > income Statement > revenue
156719000
Quarters > 0 > income Statement > cost Of Revenue
2338000
Quarters > 0 > income Statement > gross Profit
154381000
Quarters > 0 > income Statement > operating Expenses
314563000
Quarters > 0 > income Statement > operating Income
-160182000
Quarters > 0 > income Statement > interest Expense
22164000
Quarters > 0 > income Statement > pretax Income
-128393000
Quarters > 0 > income Statement > net Income
-128606000
Quarters > 0 > income Statement > eps
-0.7999975117879048
Quarters > 0 > income Statement > dividends Per Share
-
Quarters > 0 > income Statement > shares Outstanding
160758000
Quarters > 0 > income Statement > income Tax Expense
213000
Quarters > 0 > income Statement > EBITDA
-94378000
Quarters > 0 > income Statement > operating Margin
-102.20968740229328
Quarters > 0 > income Statement > total Other Income Expense Net
31789000
Quarters > 0 > income Statement > currency_symbol
-
Quarters > 0 > balance Sheet > cash
338341000
Quarters > 0 > balance Sheet > short Term Investments
1901830000
Quarters > 0 > balance Sheet > receivables
25000000
Quarters > 0 > balance Sheet > inventories
10470000
Quarters > 0 > balance Sheet > total Current Assets
2518993000
Quarters > 0 > balance Sheet > property Plant Equipment
348110000
Quarters > 0 > balance Sheet > total Assets
3033091000
Quarters > 0 > balance Sheet > payables
14326000
Quarters > 0 > balance Sheet > short Term Debt
630911000
Quarters > 0 > balance Sheet > long Term Debt
-
Quarters > 0 > balance Sheet > total Liabilities
2415124000
Quarters > 0 > balance Sheet > equity
617967000
Quarters > 0 > balance Sheet > currency_symbol
-
Quarters > 0 > cash Flow > net Income
-128606000
Quarters > 0 > cash Flow > depreciation
11851000
Quarters > 0 > cash Flow > change In Working Capital
69658000
Quarters > 0 > cash Flow > cash From Operations
-131437000
Quarters > 0 > cash Flow > capital Expenditures
3306000
Quarters > 0 > cash Flow > cash From Investing
91338000
Quarters > 0 > cash Flow > cash From Financing
81218000
Quarters > 0 > cash Flow > net Change In Cash
41037000
Quarters > 0 > cash Flow > currency_symbol
-
Quarters > 0 > ratios > PE
-0.7999975117879048
Quarters > 0 > ratios > PB
21.78028228303453
Quarters > 0 > ratios > ROE
-20.81114363711978
Quarters > 0 > ratios > ROA
-4.240096983572204
Quarters > 0 > ratios > FCF
-134743000
Quarters > 0 > ratios > Piotroski FScore
0
Quarters > 0 > ratios > fcf Percent
-0.8597745008582239
Quarters > 0 > health Score
8
Quarters > 1 > quarter
2025-06-30
Quarters > 1 > income Statement > revenue
452049000
Quarters > 1 > income Statement > cost Of Revenue
4151000
Quarters > 1 > income Statement > gross Profit
447898000
Quarters > 1 > income Statement > operating Expenses
308082000
Quarters > 1 > income Statement > operating Income
139816000
Quarters > 1 > income Statement > interest Expense
22762000
Quarters > 1 > income Statement > pretax Income
123531000
Quarters > 1 > income Statement > net Income
123551000
Quarters > 1 > income Statement > eps
0.6776192748353269
Quarters > 1 > income Statement > dividends Per Share
-
Quarters > 1 > income Statement > shares Outstanding
182331000
Quarters > 1 > income Statement > income Tax Expense
-20000
Quarters > 1 > income Statement > EBITDA
150233000
Quarters > 1 > income Statement > operating Margin
30.929390397943585
Quarters > 1 > income Statement > total Other Income Expense Net
-16285000
Quarters > 1 > income Statement > currency_symbol
-
Quarters > 1 > balance Sheet > cash
297304000
Quarters > 1 > balance Sheet > short Term Investments
1992676000
Quarters > 1 > balance Sheet > receivables
52580000
Quarters > 1 > balance Sheet > inventories
8481000
Quarters > 1 > balance Sheet > total Current Assets
2577150000
Quarters > 1 > balance Sheet > property Plant Equipment
275884000
Quarters > 1 > balance Sheet > total Assets
2985133000
Quarters > 1 > balance Sheet > payables
22800000
Quarters > 1 > balance Sheet > short Term Debt
630118000
Quarters > 1 > balance Sheet > long Term Debt
-
Quarters > 1 > balance Sheet > total Liabilities
2353409000
Quarters > 1 > balance Sheet > equity
631724000
Quarters > 1 > balance Sheet > currency_symbol
-
Quarters > 1 > cash Flow > net Income
123551000
Quarters > 1 > cash Flow > depreciation
5454000
Quarters > 1 > cash Flow > change In Working Capital
-28483000
Quarters > 1 > cash Flow > cash From Operations
151338000
Quarters > 1 > cash Flow > capital Expenditures
14269000
Quarters > 1 > cash Flow > cash From Investing
-120068000
Quarters > 1 > cash Flow > cash From Financing
1247000
Quarters > 1 > cash Flow > net Change In Cash
33112000
Quarters > 1 > cash Flow > currency_symbol
USD
Quarters > 1 > ratios > PE
0.6776192748353269
Quarters > 1 > ratios > PB
24.165140854550405
Quarters > 1 > ratios > ROE
19.557749903438843
Quarters > 1 > ratios > ROA
4.138877564249231
Quarters > 1 > ratios > FCF
137069000
Quarters > 1 > ratios > Piotroski FScore
4
Quarters > 1 > ratios > fcf Percent
0.3032171291165338
Quarters > 1 > health Score
62
Quarters > 2 > quarter
2025-03-31
Quarters > 2 > income Statement > revenue
131612000
Quarters > 2 > income Statement > cost Of Revenue
1500000
Quarters > 2 > income Statement > gross Profit
130112000
Quarters > 2 > income Statement > operating Expenses
276972000
Quarters > 2 > income Statement > operating Income
-146860000
Quarters > 2 > income Statement > interest Expense
22930000
Quarters > 2 > income Statement > pretax Income
-146822000
Quarters > 2 > income Statement > net Income
-146938000
Quarters > 2 > income Statement > eps
-0.9256811667244149
Quarters > 2 > income Statement > dividends Per Share
-
Quarters > 2 > income Statement > shares Outstanding
158735000
Quarters > 2 > income Statement > income Tax Expense
116000
Quarters > 2 > income Statement > EBITDA
-120003000
Quarters > 2 > income Statement > operating Margin
-111.58556970489013
Quarters > 2 > income Statement > total Other Income Expense Net
38000
Quarters > 2 > income Statement > currency_symbol
-
Quarters > 2 > balance Sheet > cash
264192000
Quarters > 2 > balance Sheet > short Term Investments
1880960000
Quarters > 2 > balance Sheet > receivables
39707000
Quarters > 2 > balance Sheet > inventories
11502000
Quarters > 2 > balance Sheet > total Current Assets
2418932000
Quarters > 2 > balance Sheet > property Plant Equipment
262194000
Quarters > 2 > balance Sheet > total Assets
2812948000
Quarters > 2 > balance Sheet > payables
17456000
Quarters > 2 > balance Sheet > short Term Debt
12002000
Quarters > 2 > balance Sheet > long Term Debt
-
Quarters > 2 > balance Sheet > total Liabilities
2337222000
Quarters > 2 > balance Sheet > equity
475726000
Quarters > 2 > balance Sheet > currency_symbol
-
Quarters > 2 > cash Flow > net Income
-146938000
Quarters > 2 > cash Flow > depreciation
4815000000
Quarters > 2 > cash Flow > change In Working Capital
-41175000
Quarters > 2 > cash Flow > cash From Operations
-150775000
Quarters > 2 > cash Flow > capital Expenditures
12577000
Quarters > 2 > cash Flow > cash From Investing
170459000
Quarters > 2 > cash Flow > cash From Financing
2199000
Quarters > 2 > cash Flow > net Change In Cash
22115000
Quarters > 2 > cash Flow > currency_symbol
USD
Quarters > 2 > ratios > PE
-0.9256811667244149
Quarters > 2 > ratios > PB
27.936500468757227
Quarters > 2 > ratios > ROE
-30.887107284445246
Quarters > 2 > ratios > ROA
-5.22363015597871
Quarters > 2 > ratios > FCF
-163352000
Quarters > 2 > ratios > Piotroski FScore
0
Quarters > 2 > ratios > fcf Percent
-1.2411634197489592
Quarters > 2 > health Score
8
Quarters > 3 > quarter
2024-12-31
Quarters > 3 > income Statement > revenue
226576000
Quarters > 3 > income Statement > cost Of Revenue
3830000
Quarters > 3 > income Statement > gross Profit
222746000
Quarters > 3 > income Statement > operating Expenses
333569000
Quarters > 3 > income Statement > operating Income
-110823000
Quarters > 3 > income Statement > interest Expense
22860000
Quarters > 3 > income Statement > pretax Income
-107039000
Quarters > 3 > income Statement > net Income
-104349000
Quarters > 3 > income Statement > eps
-0.6604367088607594
Quarters > 3 > income Statement > dividends Per Share
-
Quarters > 3 > income Statement > shares Outstanding
158000000
Quarters > 3 > income Statement > income Tax Expense
-2690000
Quarters > 3 > income Statement > EBITDA
-80503000
Quarters > 3 > income Statement > operating Margin
-48.91206482593037
Quarters > 3 > income Statement > total Other Income Expense Net
3784000
Quarters > 3 > income Statement > currency_symbol
-
Quarters > 3 > balance Sheet > cash
242077000
Quarters > 3 > balance Sheet > short Term Investments
2055579000
Quarters > 3 > balance Sheet > receivables
92188000
Quarters > 3 > balance Sheet > inventories
12512000
Quarters > 3 > balance Sheet > total Current Assets
2620290000
Quarters > 3 > balance Sheet > property Plant Equipment
256107000
Quarters > 3 > balance Sheet > total Assets
3003675000
Quarters > 3 > balance Sheet > payables
42964000
Quarters > 3 > balance Sheet > short Term Debt
9279000
Quarters > 3 > balance Sheet > long Term Debt
-
Quarters > 3 > balance Sheet > total Liabilities
2415324000
Quarters > 3 > balance Sheet > equity
588351000
Quarters > 3 > balance Sheet > currency_symbol
-
Quarters > 3 > cash Flow > net Income
-104349000
Quarters > 3 > cash Flow > depreciation
5267000
Quarters > 3 > cash Flow > change In Working Capital
-61385000
Quarters > 3 > cash Flow > cash From Operations
-116139000
Quarters > 3 > cash Flow > capital Expenditures
25497000
Quarters > 3 > cash Flow > cash From Investing
68213000
Quarters > 3 > cash Flow > cash From Financing
-44116000
Quarters > 3 > cash Flow > net Change In Cash
-92528000
Quarters > 3 > cash Flow > currency_symbol
USD
Quarters > 3 > ratios > PE
-0.6604367088607594
Quarters > 3 > ratios > PB
22.48416608453117
Quarters > 3 > ratios > ROE
-17.735841360004486
Quarters > 3 > ratios > ROA
-3.4740442957377216
Quarters > 3 > ratios > FCF
-141636000
Quarters > 3 > ratios > Piotroski FScore
0
Quarters > 3 > ratios > fcf Percent
-0.6251147517830662
Quarters > 3 > health Score
8
Annuals > 0 > quarter
2024-12-31
Annuals > 0 > income Statement > revenue
705138000
Annuals > 0 > income Statement > cost Of Revenue
11215000
Annuals > 0 > income Statement > gross Profit
693923000
Annuals > 0 > income Statement > operating Expenses
1169004000
Annuals > 0 > income Statement > operating Income
-475081000
Annuals > 0 > income Statement > interest Expense
90451000
Annuals > 0 > income Statement > pretax Income
-460068000
Annuals > 0 > income Statement > net Income
-453897000
Annuals > 0 > income Statement > eps
-3.0358160439825035
Annuals > 0 > income Statement > dividends Per Share
-
Annuals > 0 > income Statement > shares Outstanding
149514000
Annuals > 0 > income Statement > income Tax Expense
-6171000
Annuals > 0 > income Statement > EBITDA
-353721000
Annuals > 0 > income Statement > operating Margin
-67.37418774764656
Annuals > 0 > income Statement > total Other Income Expense Net
15013000
Annuals > 0 > income Statement > currency_symbol
-
Annuals > 0 > balance Sheet > cash
242077000
Annuals > 0 > balance Sheet > short Term Investments
2055579000
Annuals > 0 > balance Sheet > receivables
92188000
Annuals > 0 > balance Sheet > inventories
12512000
Annuals > 0 > balance Sheet > total Current Assets
2620290000
Annuals > 0 > balance Sheet > property Plant Equipment
256107000
Annuals > 0 > balance Sheet > total Assets
3003675000
Annuals > 0 > balance Sheet > payables
42964000
Annuals > 0 > balance Sheet > short Term Debt
9279000
Annuals > 0 > balance Sheet > long Term Debt
-
Annuals > 0 > balance Sheet > total Liabilities
2415324000
Annuals > 0 > balance Sheet > equity
588351000
Annuals > 0 > balance Sheet > currency_symbol
-
Annuals > 0 > cash Flow > net Income
-453897000
Annuals > 0 > cash Flow > depreciation
19654000
Annuals > 0 > cash Flow > change In Working Capital
-209390000
Annuals > 0 > cash Flow > cash From Operations
-500947000
Annuals > 0 > cash Flow > capital Expenditures
45280000
Annuals > 0 > cash Flow > cash From Investing
-134027000
Annuals > 0 > cash Flow > cash From Financing
478058000
Annuals > 0 > cash Flow > net Change In Cash
-157189000
Annuals > 0 > cash Flow > currency_symbol
-
Annuals > 0 > ratios > PE
-3.0358160439825035
Annuals > 0 > ratios > PB
21.276567139003756
Annuals > 0 > ratios > ROE
-77.14731512311528
Annuals > 0 > ratios > ROA
-15.11138854902744
Annuals > 0 > ratios > FCF
-546227000
Annuals > 0 > ratios > Piotroski FScore
1
Annuals > 0 > ratios > fcf Percent
-0.7746384395678576
Annuals > 0 > health Score
9
Annuals > 1 > quarter
2023-12-31
Annuals > 1 > income Statement > revenue
787647000
Annuals > 1 > income Statement > cost Of Revenue
9133000
Annuals > 1 > income Statement > gross Profit
778514000
Annuals > 1 > income Statement > operating Expenses
1132244000
Annuals > 1 > income Statement > operating Income
-353730000
Annuals > 1 > income Statement > interest Expense
81457000
Annuals > 1 > income Statement > pretax Income
-333965000
Annuals > 1 > income Statement > net Income
-366286000
Annuals > 1 > income Statement > eps
-2.5580417626929255
Annuals > 1 > income Statement > dividends Per Share
-
Annuals > 1 > income Statement > shares Outstanding
143190000
Annuals > 1 > income Statement > income Tax Expense
32321000
Annuals > 1 > income Statement > EBITDA
-235870000
Annuals > 1 > income Statement > operating Margin
-44.909712091838095
Annuals > 1 > income Statement > total Other Income Expense Net
19765000
Annuals > 1 > income Statement > currency_symbol
-
Annuals > 1 > balance Sheet > cash
399266000
Annuals > 1 > balance Sheet > short Term Investments
1931935000
Annuals > 1 > balance Sheet > receivables
97778000
Annuals > 1 > balance Sheet > inventories
7441000
Annuals > 1 > balance Sheet > total Current Assets
2641853000
Annuals > 1 > balance Sheet > property Plant Equipment
242939000
Annuals > 1 > balance Sheet > total Assets
2990072000
Annuals > 1 > balance Sheet > payables
26027000
Annuals > 1 > balance Sheet > short Term Debt
53163000
Annuals > 1 > balance Sheet > long Term Debt
-
Annuals > 1 > balance Sheet > total Liabilities
2603386000
Annuals > 1 > balance Sheet > equity
386686000
Annuals > 1 > balance Sheet > currency_symbol
-
Annuals > 1 > cash Flow > net Income
-366286000
Annuals > 1 > cash Flow > depreciation
22498000
Annuals > 1 > cash Flow > change In Working Capital
-77260000
Annuals > 1 > cash Flow > cash From Operations
-307513000
Annuals > 1 > cash Flow > capital Expenditures
28011000
Annuals > 1 > cash Flow > cash From Investing
-214127000
Annuals > 1 > cash Flow > cash From Financing
644082000
Annuals > 1 > cash Flow > net Change In Cash
122794000
Annuals > 1 > cash Flow > currency_symbol
USD
Annuals > 1 > ratios > PE
-2.5580417626929255
Annuals > 1 > ratios > PB
31.00347927776025
Annuals > 1 > ratios > ROE
-94.72440171094894
Annuals > 1 > ratios > ROA
-12.250072907943354
Annuals > 1 > ratios > FCF
-335524000
Annuals > 1 > ratios > Piotroski FScore
0
Annuals > 1 > ratios > fcf Percent
-0.4259827054505381
Annuals > 1 > health Score
8
Annuals > 2 > quarter
2022-12-31
Annuals > 2 > income Statement > revenue
587367000
Annuals > 2 > income Statement > cost Of Revenue
14116000
Annuals > 2 > income Statement > gross Profit
573251000
Annuals > 2 > income Statement > operating Expenses
983442000
Annuals > 2 > income Statement > operating Income
-410191000
Annuals > 2 > income Statement > interest Expense
8122000
Annuals > 2 > income Statement > pretax Income
-257985000
Annuals > 2 > income Statement > net Income
-269722000
Annuals > 2 > income Statement > eps
-1.9014860977948227
Annuals > 2 > income Statement > dividends Per Share
-
Annuals > 2 > income Statement > shares Outstanding
141848000
Annuals > 2 > income Statement > income Tax Expense
11737000
Annuals > 2 > income Statement > EBITDA
-227758000
Annuals > 2 > income Statement > operating Margin
-69.83555426164561
Annuals > 2 > income Statement > total Other Income Expense Net
152206000
Annuals > 2 > income Statement > currency_symbol
-
Annuals > 2 > balance Sheet > cash
276472000
Annuals > 2 > balance Sheet > short Term Investments
1720936000
Annuals > 2 > balance Sheet > receivables
25538000
Annuals > 2 > balance Sheet > inventories
22033000
Annuals > 2 > balance Sheet > total Current Assets
2202694000
Annuals > 2 > balance Sheet > property Plant Equipment
255838000
Annuals > 2 > balance Sheet > total Assets
2533876000
Annuals > 2 > balance Sheet > payables
17921000
Annuals > 2 > balance Sheet > short Term Debt
7535000
Annuals > 2 > balance Sheet > long Term Debt
-
Annuals > 2 > balance Sheet > total Liabilities
1960989000
Annuals > 2 > balance Sheet > equity
572887000
Annuals > 2 > balance Sheet > currency_symbol
-
Annuals > 2 > cash Flow > net Income
-269722000
Annuals > 2 > cash Flow > depreciation
22105000
Annuals > 2 > cash Flow > change In Working Capital
7571000
Annuals > 2 > cash Flow > cash From Operations
-274370000
Annuals > 2 > cash Flow > capital Expenditures
20099000
Annuals > 2 > cash Flow > cash From Investing
-262636000
Annuals > 2 > cash Flow > cash From Financing
-55295000
Annuals > 2 > cash Flow > net Change In Cash
-592719000
Annuals > 2 > cash Flow > currency_symbol
USD
Annuals > 2 > ratios > PE
-1.9014860977948227
Annuals > 2 > ratios > PB
20.730531797021055
Annuals > 2 > ratios > ROE
-47.0811870403762
Annuals > 2 > ratios > ROA
-10.644640858510835
Annuals > 2 > ratios > FCF
-294469000
Annuals > 2 > ratios > Piotroski FScore
1
Annuals > 2 > ratios > fcf Percent
-0.5013373240239918
Annuals > 2 > health Score
9
Annuals > 3 > quarter
2021-12-31
Annuals > 3 > income Statement > revenue
810456000
Annuals > 3 > income Statement > cost Of Revenue
10842000
Annuals > 3 > income Statement > gross Profit
799614000
Annuals > 3 > income Statement > operating Expenses
829800000
Annuals > 3 > income Statement > operating Income
-30186000
Annuals > 3 > income Statement > interest Expense
9349000
Annuals > 3 > income Statement > pretax Income
-29148000
Annuals > 3 > income Statement > net Income
-28597000
Annuals > 3 > income Statement > eps
-0.20278540075591578
Annuals > 3 > income Statement > dividends Per Share
-
Annuals > 3 > income Statement > shares Outstanding
141021000
Annuals > 3 > income Statement > income Tax Expense
-551000
Annuals > 3 > income Statement > EBITDA
-5188000
Annuals > 3 > income Statement > operating Margin
-3.7245698717758895
Annuals > 3 > income Statement > total Other Income Expense Net
1038000
Annuals > 3 > income Statement > currency_symbol
-
Annuals > 3 > balance Sheet > cash
869191000
Annuals > 3 > balance Sheet > short Term Investments
1263987000
Annuals > 3 > balance Sheet > receivables
61896000
Annuals > 3 > balance Sheet > inventories
24806000
Annuals > 3 > balance Sheet > total Current Assets
2345049000
Annuals > 3 > balance Sheet > property Plant Equipment
196043000
Annuals > 3 > balance Sheet > total Assets
2611690000
Annuals > 3 > balance Sheet > payables
11904000
Annuals > 3 > balance Sheet > short Term Debt
3526000
Annuals > 3 > balance Sheet > long Term Debt
-
Annuals > 3 > balance Sheet > total Liabilities
1839953000
Annuals > 3 > balance Sheet > equity
771737000
Annuals > 3 > balance Sheet > currency_symbol
-
Annuals > 3 > cash Flow > net Income
-28597000
Annuals > 3 > cash Flow > depreciation
19560000
Annuals > 3 > cash Flow > change In Working Capital
-113818000
Annuals > 3 > cash Flow > cash From Operations
30799000
Annuals > 3 > cash Flow > capital Expenditures
17901000
Annuals > 3 > cash Flow > cash From Investing
194906000
Annuals > 3 > cash Flow > cash From Financing
245933000
Annuals > 3 > cash Flow > net Change In Cash
471527000
Annuals > 3 > cash Flow > currency_symbol
USD
Annuals > 3 > ratios > PE
-0.20278540075591578
Annuals > 3 > ratios > PB
15.299268311873087
Annuals > 3 > ratios > ROE
-3.705536989933099
Annuals > 3 > ratios > ROA
-1.094961500024888
Annuals > 3 > ratios > FCF
12898000
Annuals > 3 > ratios > Piotroski FScore
2
Annuals > 3 > ratios > fcf Percent
0.015914497517446967
Annuals > 3 > health Score
13
Valuation > metrics > PE
-0.7999975117879048
Valuation > metrics > PB
21.78028228303453
Valuation > final Score
20
Valuation > verdict
626.0% Overvalued
Profitability > metrics > ROE
-20.81114363711978
Profitability > metrics > ROA
-5.105452853580776
Profitability > metrics > Net Margin
-0.8206152412917387
Profitability > final Score
0
Profitability > verdict
Weak
Risk > metrics > Debt Equity
3.9081763265675997
Risk > metrics > Interest Coverage
-7.227125067677314
Risk > final Score
-23
Risk > verdict
High
Liquidity > metrics > Current Ratio
3.903981017827558
Liquidity > metrics > Quick Ratio
3.8877544220185762
Liquidity > final Score
100
Liquidity > verdict
Great
Prev Valuations > 0
40
Prev Valuations > 1
20
Prev Valuations > 2
20
Prev Profitabilities > 0
83
Prev Profitabilities > 1
0
Prev Profitabilities > 2
0
Prev Risks > 0
31
Prev Risks > 1
-20
Prev Risks > 2
-13
Prev Liquidities > 0
100
Prev Liquidities > 1
100
Prev Liquidities > 2
100
Updated At
2026-01-22T21:23:00.053Z
Earnings History > 0 > period
2025-12-31
Earnings History > 0 > report Date
2026-02-18
Earnings History > 0 > date
2025-12-31
Earnings History > 0 > before After Market
BeforeMarket
Earnings History > 0 > currency
-
Earnings History > 0 > eps Actual
-
Earnings History > 0 > eps Estimate
-1.25
Earnings History > 0 > eps Difference
0
Earnings History > 0 > surprise Percent
-
Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA). It also provides QALSODY for the treatment of Amyotrophic Lateral Sclerosis (ALS); TEGSEDI for the treatment of ATTRv-PN in adults; and WAYLIVRA for treatment for FCS and familial partial lipodystrophy. It also develops products under Phase 3 clinical trials, such as Olezarsen for patients with hypertriglyceridemia (SHTG) and cardiovascular disease (CVD); Donidalorsen for patients with hereditary angioedema; and Zilganerse, a potential treatment for people with genetically confirmed Alexander disease, as well as ION582 that has completed Phase 2 clinical trial for the potential treatment of AS, a rare genetic neurological disease. In addition, the company develops Eplontersen to degrade mutant and wild-type TTR mRNA through binding to the TTR mRNA; Pelacarsen to inhibit the production of apolipoprotein(a) in the liver to offer a direct approach for reducing lipoprotein(a); Bepirovirsen to inhibit the production of viral proteins associated with hepatitis B virus; Sefaxersen to reduce the production of complement factor B and lower activation of the alternative complement pathway; and Ulefnersen to reduce the production of the fused in sarcoma, as well as other mid-stage pipeline investigational medicines. It has a strategic collaboration with Biogen for the treatment of neurological disorders; and collaboration and license agreement with GSK, AstraZeneca, Novartis, and Roche, as well as with Metagenomi. The company was incorporated in 1989 and is headquartered in Carlsbad, California.
Stock Price
$0.00
decrease compared to yesterday.
Dividend
Frequency:
Rate:
N/ANext Payout:
N/A(Last Updated 2025-10-28)
Health Score
Price to Book Ratio (P/B)
-
Very High
Low ≤ 1
High ≥ 3
Return on Equity (ROE)
-
Very Low
Low ≤ 5%
High ≥ 25%
Return on Assets (ROA)
-
Very Low
Low ≤ 2%
High ≥ 10%
Free Cash Flow - Revenue % (FCF)
-
Very Low
Low ≤ 5%
High ≥ 15%
Debt to Equity
-
Very Low
Low ≥ 1
High ≤ 0.3
* Institutions hold a combined 0.00% of the total shares of Ionis Pharmaceuticals, Inc.
* Investors data is estimated based on stocks listed on Finnton that are currently held by Institution/Fund.
Date
2025-12-31
EPS Estimate
-1.25
Date
—
EPS Actual
—
EPS Estimate
—
EPS Difference
—
Surprise Percent
undefined%
(Last Updated 2025-10-28)
(Last Updated 2025-10-28)
Revenue
$ 0
Cost Of Revenue
$ 0
Gross Profit
$ 0
Operating Expenses
$ 0
Operating Income
$ 0
Interest Expense
$ 0
Pretax Income
$ 0
Net Income
$ 0
Income Tax Expense
$ 0
EBITDA
$ 0
Total Other Income Expense Net
$ 0
Earnings Per Share
0
Dividends Per Share
0
Shares Outstanding
0
Operating Margin
0%
(Last Updated 2025-10-28)
Cash
$ 0
Short Term Investments
$ 0
Receivables
$ 0
Inventories
$ 0
Total Current Assets
$ 0
Property Plant Equipment
$ 0
Total Assets
$ 0
Payables
$ 0
Short Term Debt
$ 0
Long Term Debt
$ 0
Total Liabilities
$ 0
Equity
$ 0
(Last Updated 2025-10-28)
Net Income
$ 0
Depreciation
$ 0
Change In Working Capital
$ 0
Cash From Operations
$ 0
Capital Expenditures
$ 0
Cash From Investing
$ 0
Cash From Financing
$ 0
Net Change In Cash
$ 0
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