_id
69171b113c536f8df23165f1
Ticker
SYRE
Name
Spyre Therapeutics Inc.
Exchange
NASDAQ
Address
221 Crescent Street, Waltham, MA, United States, 02453
Country
USA
Sector
Healthcare
Industry
Biotechnology
Currency
USD
Website
https://www.spyre.com
Description
Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.
Last Close
29.92
Volume
752162
Current Price
33.24
Change
0.37
Last Updated
2026-01-07T12:45:44.579Z
Image
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Ipo Date
2016-04-07T00:00:00.000Z
Market Cap
2353369344
Next Dividend Date
-
Dividend Frequency
-
Dividend Rate
-
Dividend Yield
0
Sentiment
0.995
Sentiment Sources
1
Rating
4.8182
Target Price
54.2857
Strong Buy
10
Buy
0
Hold
1
Sell
0
Strong Sell
0
Current Quarter
2025-09-30
Revenue
0
Cost Of Revenue
45247000
Gross Profit
-45247000
Operating Expenses
11641000
Operating Income
-56888000
Interest Expense
-
Pretax Income
-11183000
Net Income
-11183000
Eps
-0.18510541797417474
Dividends Per Share
-
Shares Outstanding
77592130
Income Tax Expense
-
EBITDA
-11183000
Operating Margin
-
Total Other Income Expense Net
45705000
Cash
64897000
Short Term Investments
421301000
Receivables
3600000
Inventories
-
Total Current Assets
504604000
Property Plant Equipment
-
Total Assets
504604000
Payables
7457000
Short Term Debt
-
Long Term Debt
-
Total Liabilities
49504000
Equity
455100000
Bs_currency_symbol
USD
Depreciation
-
Change In Working Capital
5940000
Cash From Operations
-37117000
Capital Expenditures
0
Cash From Investing
24998000
Cash From Financing
-4643000
Net Change In Cash
-16762000
Cf_currency_symbol
USD
PE
-
PB
4.41258794225445
ROE
-2.4572621401889694
ROA
-2.216193292165738
FCF
-37117000
Fcf Percent
-
Piotroski FScore
0
Health Score
37
Deep Value Investing Score
3.5
Defensive Investing Score
7
Dividend Investing Score
1.5
Economic Moat Investing Score
4.3
Garp Investing Score
2
Growth Investing Score
0.5
Momentum Investing Score
2.5
Net Net Investing Score
2.5
Quality Investing Score
3
Value Investing Score
5
Quarters > 0 > quarter
2025-09-30
Quarters > 0 > income Statement > revenue
0
Quarters > 0 > income Statement > cost Of Revenue
45247000
Quarters > 0 > income Statement > gross Profit
-45247000
Quarters > 0 > income Statement > operating Expenses
11641000
Quarters > 0 > income Statement > operating Income
-56888000
Quarters > 0 > income Statement > interest Expense
-
Quarters > 0 > income Statement > pretax Income
-11183000
Quarters > 0 > income Statement > net Income
-11183000
Quarters > 0 > income Statement > eps
-0.18510541797417474
Quarters > 0 > income Statement > dividends Per Share
-
Quarters > 0 > income Statement > shares Outstanding
60414223
Quarters > 0 > income Statement > income Tax Expense
-
Quarters > 0 > income Statement > EBITDA
-11183000
Quarters > 0 > income Statement > operating Margin
-
Quarters > 0 > income Statement > total Other Income Expense Net
45705000
Quarters > 0 > income Statement > currency_symbol
USD
Quarters > 0 > balance Sheet > cash
64897000
Quarters > 0 > balance Sheet > short Term Investments
421301000
Quarters > 0 > balance Sheet > receivables
3600000
Quarters > 0 > balance Sheet > inventories
-
Quarters > 0 > balance Sheet > total Current Assets
504604000
Quarters > 0 > balance Sheet > property Plant Equipment
-
Quarters > 0 > balance Sheet > total Assets
504604000
Quarters > 0 > balance Sheet > payables
7457000
Quarters > 0 > balance Sheet > short Term Debt
-
Quarters > 0 > balance Sheet > long Term Debt
-
Quarters > 0 > balance Sheet > total Liabilities
49504000
Quarters > 0 > balance Sheet > equity
455100000
Quarters > 0 > balance Sheet > currency_symbol
USD
Quarters > 0 > cash Flow > net Income
-11183000
Quarters > 0 > cash Flow > depreciation
-
Quarters > 0 > cash Flow > change In Working Capital
5940000
Quarters > 0 > cash Flow > cash From Operations
-37117000
Quarters > 0 > cash Flow > capital Expenditures
0
Quarters > 0 > cash Flow > cash From Investing
24998000
Quarters > 0 > cash Flow > cash From Financing
-4643000
Quarters > 0 > cash Flow > net Change In Cash
-16762000
Quarters > 0 > cash Flow > currency_symbol
USD
Quarters > 0 > ratios > PE
-0.18510541797417474
Quarters > 0 > ratios > PB
4.41258794225445
Quarters > 0 > ratios > ROE
-2.4572621401889694
Quarters > 0 > ratios > ROA
-2.216193292165738
Quarters > 0 > ratios > FCF
-37117000
Quarters > 0 > ratios > Piotroski FScore
0
Quarters > 0 > ratios > fcf Percent
-
Quarters > 0 > health Score
37
Quarters > 1 > quarter
2025-06-30
Quarters > 1 > income Statement > revenue
0
Quarters > 1 > income Statement > cost Of Revenue
-
Quarters > 1 > income Statement > gross Profit
-
Quarters > 1 > income Statement > operating Expenses
41935000
Quarters > 1 > income Statement > operating Income
-41935000
Quarters > 1 > income Statement > interest Expense
-
Quarters > 1 > income Statement > pretax Income
-36717000
Quarters > 1 > income Statement > net Income
-36717000
Quarters > 1 > income Statement > eps
-0.6049272981742785
Quarters > 1 > income Statement > dividends Per Share
-
Quarters > 1 > income Statement > shares Outstanding
60696550
Quarters > 1 > income Statement > income Tax Expense
-
Quarters > 1 > income Statement > EBITDA
-51935000
Quarters > 1 > income Statement > operating Margin
-
Quarters > 1 > income Statement > total Other Income Expense Net
5218000
Quarters > 1 > income Statement > currency_symbol
USD
Quarters > 1 > balance Sheet > cash
81659000
Quarters > 1 > balance Sheet > short Term Investments
444921000
Quarters > 1 > balance Sheet > receivables
3500000
Quarters > 1 > balance Sheet > inventories
-
Quarters > 1 > balance Sheet > total Current Assets
538832000
Quarters > 1 > balance Sheet > property Plant Equipment
-
Quarters > 1 > balance Sheet > total Assets
538832000
Quarters > 1 > balance Sheet > payables
3712000
Quarters > 1 > balance Sheet > short Term Debt
-
Quarters > 1 > balance Sheet > long Term Debt
-
Quarters > 1 > balance Sheet > total Liabilities
83059000
Quarters > 1 > balance Sheet > equity
455773000
Quarters > 1 > balance Sheet > currency_symbol
USD
Quarters > 1 > cash Flow > net Income
-36717000
Quarters > 1 > cash Flow > depreciation
-
Quarters > 1 > cash Flow > change In Working Capital
-9041000
Quarters > 1 > cash Flow > cash From Operations
-46563000
Quarters > 1 > cash Flow > capital Expenditures
0
Quarters > 1 > cash Flow > cash From Investing
78998000
Quarters > 1 > cash Flow > cash From Financing
731000
Quarters > 1 > cash Flow > net Change In Cash
33166000
Quarters > 1 > cash Flow > currency_symbol
USD
Quarters > 1 > ratios > PE
-0.6049272981742785
Quarters > 1 > ratios > PB
4.426662663211731
Quarters > 1 > ratios > ROE
-8.055984009583717
Quarters > 1 > ratios > ROA
-6.814183270481338
Quarters > 1 > ratios > FCF
-46563000
Quarters > 1 > ratios > Piotroski FScore
0
Quarters > 1 > ratios > fcf Percent
-
Quarters > 1 > health Score
37
Quarters > 2 > quarter
2025-03-31
Quarters > 2 > income Statement > revenue
0
Quarters > 2 > income Statement > cost Of Revenue
-
Quarters > 2 > income Statement > gross Profit
-
Quarters > 2 > income Statement > operating Expenses
53567000
Quarters > 2 > income Statement > operating Income
-53567000
Quarters > 2 > income Statement > interest Expense
-
Quarters > 2 > income Statement > pretax Income
-44788000
Quarters > 2 > income Statement > net Income
-44773000
Quarters > 2 > income Statement > eps
-0.7429238794481765
Quarters > 2 > income Statement > dividends Per Share
-
Quarters > 2 > income Statement > shares Outstanding
60265932
Quarters > 2 > income Statement > income Tax Expense
-15000
Quarters > 2 > income Statement > EBITDA
-53567000
Quarters > 2 > income Statement > operating Margin
-
Quarters > 2 > income Statement > total Other Income Expense Net
8779000
Quarters > 2 > income Statement > currency_symbol
USD
Quarters > 2 > balance Sheet > cash
48493000
Quarters > 2 > balance Sheet > short Term Investments
516327000
Quarters > 2 > balance Sheet > receivables
-
Quarters > 2 > balance Sheet > inventories
-
Quarters > 2 > balance Sheet > total Current Assets
569768000
Quarters > 2 > balance Sheet > property Plant Equipment
-
Quarters > 2 > balance Sheet > total Assets
569778000
Quarters > 2 > balance Sheet > payables
3689000
Quarters > 2 > balance Sheet > short Term Debt
-
Quarters > 2 > balance Sheet > long Term Debt
-
Quarters > 2 > balance Sheet > total Liabilities
87168000
Quarters > 2 > balance Sheet > equity
482610000
Quarters > 2 > balance Sheet > currency_symbol
USD
Quarters > 2 > cash Flow > net Income
-44773000
Quarters > 2 > cash Flow > depreciation
-
Quarters > 2 > cash Flow > change In Working Capital
-568000
Quarters > 2 > cash Flow > cash From Operations
-40994000
Quarters > 2 > cash Flow > capital Expenditures
0
Quarters > 2 > cash Flow > cash From Investing
-61000
Quarters > 2 > cash Flow > cash From Financing
125000
Quarters > 2 > cash Flow > net Change In Cash
-40930000
Quarters > 2 > cash Flow > currency_symbol
USD
Quarters > 2 > ratios > PE
-0.7429238794481765
Quarters > 2 > ratios > PB
4.150845568222788
Quarters > 2 > ratios > ROE
-9.277263214603924
Quarters > 2 > ratios > ROA
-7.857972754300797
Quarters > 2 > ratios > FCF
-40994000
Quarters > 2 > ratios > Piotroski FScore
1
Quarters > 2 > ratios > fcf Percent
-
Quarters > 2 > health Score
38
Quarters > 3 > quarter
2024-12-31
Quarters > 3 > income Statement > revenue
0
Quarters > 3 > income Statement > cost Of Revenue
-
Quarters > 3 > income Statement > gross Profit
-
Quarters > 3 > income Statement > operating Expenses
61253000
Quarters > 3 > income Statement > operating Income
-61253000
Quarters > 3 > income Statement > interest Expense
21312000
Quarters > 3 > income Statement > pretax Income
-56295000
Quarters > 3 > income Statement > net Income
-56296000
Quarters > 3 > income Statement > eps
-1.1970832981235418
Quarters > 3 > income Statement > dividends Per Share
-
Quarters > 3 > income Statement > shares Outstanding
47027638
Quarters > 3 > income Statement > income Tax Expense
1000
Quarters > 3 > income Statement > EBITDA
-61253000
Quarters > 3 > income Statement > operating Margin
-
Quarters > 3 > income Statement > total Other Income Expense Net
4958000
Quarters > 3 > income Statement > currency_symbol
USD
Quarters > 3 > balance Sheet > cash
89423000
Quarters > 3 > balance Sheet > short Term Investments
513665000
Quarters > 3 > balance Sheet > receivables
-
Quarters > 3 > balance Sheet > inventories
-
Quarters > 3 > balance Sheet > total Current Assets
608474000
Quarters > 3 > balance Sheet > property Plant Equipment
-
Quarters > 3 > balance Sheet > total Assets
608484000
Quarters > 3 > balance Sheet > payables
666000
Quarters > 3 > balance Sheet > short Term Debt
-
Quarters > 3 > balance Sheet > long Term Debt
-
Quarters > 3 > balance Sheet > total Liabilities
90680000
Quarters > 3 > balance Sheet > equity
517804000
Quarters > 3 > balance Sheet > currency_symbol
USD
Quarters > 3 > cash Flow > net Income
-56296000
Quarters > 3 > cash Flow > depreciation
-11404000
Quarters > 3 > cash Flow > change In Working Capital
10798000
Quarters > 3 > cash Flow > cash From Operations
-37199000
Quarters > 3 > cash Flow > capital Expenditures
0
Quarters > 3 > cash Flow > cash From Investing
-170544000
Quarters > 3 > cash Flow > cash From Financing
225601000
Quarters > 3 > cash Flow > net Change In Cash
17843000
Quarters > 3 > cash Flow > currency_symbol
USD
Quarters > 3 > ratios > PE
-1.1970832981235418
Quarters > 3 > ratios > PB
3.0189003698696806
Quarters > 3 > ratios > ROE
-10.872067423194878
Quarters > 3 > ratios > ROA
-9.251845570302589
Quarters > 3 > ratios > FCF
-37199000
Quarters > 3 > ratios > Piotroski FScore
1
Quarters > 3 > ratios > fcf Percent
-
Quarters > 3 > health Score
38
Annuals > 0 > quarter
2024-12-31
Annuals > 0 > income Statement > revenue
886000
Annuals > 0 > income Statement > cost Of Revenue
964000
Annuals > 0 > income Statement > gross Profit
886000
Annuals > 0 > income Statement > operating Expenses
208566000
Annuals > 0 > income Statement > operating Income
-208566000
Annuals > 0 > income Statement > interest Expense
-
Annuals > 0 > income Statement > pretax Income
-207967000
Annuals > 0 > income Statement > net Income
-208018000
Annuals > 0 > income Statement > eps
-4.423313796878338
Annuals > 0 > income Statement > dividends Per Share
-
Annuals > 0 > income Statement > shares Outstanding
47027638
Annuals > 0 > income Statement > income Tax Expense
51000
Annuals > 0 > income Statement > EBITDA
-207967000
Annuals > 0 > income Statement > operating Margin
-23540.18058690745
Annuals > 0 > income Statement > total Other Income Expense Net
599000
Annuals > 0 > income Statement > currency_symbol
USD
Annuals > 0 > balance Sheet > cash
89423000
Annuals > 0 > balance Sheet > short Term Investments
513665000
Annuals > 0 > balance Sheet > receivables
-
Annuals > 0 > balance Sheet > inventories
-
Annuals > 0 > balance Sheet > total Current Assets
608474000
Annuals > 0 > balance Sheet > property Plant Equipment
-
Annuals > 0 > balance Sheet > total Assets
608484000
Annuals > 0 > balance Sheet > payables
666000
Annuals > 0 > balance Sheet > short Term Debt
-
Annuals > 0 > balance Sheet > long Term Debt
-
Annuals > 0 > balance Sheet > total Liabilities
90680000
Annuals > 0 > balance Sheet > equity
517804000
Annuals > 0 > balance Sheet > currency_symbol
USD
Annuals > 0 > cash Flow > net Income
-208018000
Annuals > 0 > cash Flow > depreciation
744000
Annuals > 0 > cash Flow > change In Working Capital
-4534000
Annuals > 0 > cash Flow > cash From Operations
-157410000
Annuals > 0 > cash Flow > capital Expenditures
0
Annuals > 0 > cash Flow > cash From Investing
-353285000
Annuals > 0 > cash Flow > cash From Financing
410906000
Annuals > 0 > cash Flow > net Change In Cash
-99792000
Annuals > 0 > cash Flow > currency_symbol
USD
Annuals > 0 > ratios > PE
-4.423313796878338
Annuals > 0 > ratios > PB
2.754610355539934
Annuals > 0 > ratios > ROE
-40.17311569628663
Annuals > 0 > ratios > ROA
-34.186272769703066
Annuals > 0 > ratios > FCF
-157410000
Annuals > 0 > ratios > Piotroski FScore
0
Annuals > 0 > ratios > fcf Percent
-177.66365688487585
Annuals > 0 > health Score
34
Annuals > 1 > quarter
2023-12-31
Annuals > 1 > income Statement > revenue
886000
Annuals > 1 > income Statement > cost Of Revenue
964000
Annuals > 1 > income Statement > gross Profit
-78000
Annuals > 1 > income Statement > operating Expenses
243189000
Annuals > 1 > income Statement > operating Income
-242303000
Annuals > 1 > income Statement > interest Expense
-
Annuals > 1 > income Statement > pretax Income
-338816000
Annuals > 1 > income Statement > net Income
-338790000
Annuals > 1 > income Statement > eps
-49.12089417745084
Annuals > 1 > income Statement > dividends Per Share
-
Annuals > 1 > income Statement > shares Outstanding
6897065
Annuals > 1 > income Statement > income Tax Expense
-26000
Annuals > 1 > income Statement > EBITDA
-242303000
Annuals > 1 > income Statement > operating Margin
-27347.968397291195
Annuals > 1 > income Statement > total Other Income Expense Net
-96513000
Annuals > 1 > income Statement > currency_symbol
USD
Annuals > 1 > balance Sheet > cash
188893000
Annuals > 1 > balance Sheet > short Term Investments
150384000
Annuals > 1 > balance Sheet > receivables
-
Annuals > 1 > balance Sheet > inventories
-
Annuals > 1 > balance Sheet > total Current Assets
341528000
Annuals > 1 > balance Sheet > property Plant Equipment
0
Annuals > 1 > balance Sheet > total Assets
341859000
Annuals > 1 > balance Sheet > payables
896000
Annuals > 1 > balance Sheet > short Term Debt
-
Annuals > 1 > balance Sheet > long Term Debt
-
Annuals > 1 > balance Sheet > total Liabilities
157843000
Annuals > 1 > balance Sheet > equity
184016000
Annuals > 1 > balance Sheet > currency_symbol
USD
Annuals > 1 > cash Flow > net Income
-338790000
Annuals > 1 > cash Flow > depreciation
744000
Annuals > 1 > cash Flow > change In Working Capital
-5206000
Annuals > 1 > cash Flow > cash From Operations
-99910000
Annuals > 1 > cash Flow > capital Expenditures
0
Annuals > 1 > cash Flow > cash From Investing
-
Annuals > 1 > cash Flow > cash From Financing
361077000
Annuals > 1 > cash Flow > net Change In Cash
152799000
Annuals > 1 > cash Flow > currency_symbol
USD
Annuals > 1 > ratios > PE
-49.12089417745084
Annuals > 1 > ratios > PB
1.136792352023737
Annuals > 1 > ratios > ROE
-184.10899052256326
Annuals > 1 > ratios > ROA
-99.10226145867156
Annuals > 1 > ratios > FCF
-99910000
Annuals > 1 > ratios > Piotroski FScore
1
Annuals > 1 > ratios > fcf Percent
-112.76523702031602
Annuals > 1 > health Score
31
Annuals > 2 > quarter
2022-12-31
Annuals > 2 > income Statement > revenue
2329000
Annuals > 2 > income Statement > cost Of Revenue
1964000
Annuals > 2 > income Statement > gross Profit
2329000
Annuals > 2 > income Statement > operating Expenses
87110000
Annuals > 2 > income Statement > operating Income
-84781000
Annuals > 2 > income Statement > interest Expense
-
Annuals > 2 > income Statement > pretax Income
-83951000
Annuals > 2 > income Statement > net Income
-83815000
Annuals > 2 > income Statement > eps
-24.861838301795398
Annuals > 2 > income Statement > dividends Per Share
-
Annuals > 2 > income Statement > shares Outstanding
3371231
Annuals > 2 > income Statement > income Tax Expense
-136000
Annuals > 2 > income Statement > EBITDA
-82817000
Annuals > 2 > income Statement > operating Margin
-3640.2318591670246
Annuals > 2 > income Statement > total Other Income Expense Net
830000
Annuals > 2 > income Statement > currency_symbol
USD
Annuals > 2 > balance Sheet > cash
34863000
Annuals > 2 > balance Sheet > short Term Investments
20848000
Annuals > 2 > balance Sheet > receivables
375000
Annuals > 2 > balance Sheet > inventories
-
Annuals > 2 > balance Sheet > total Current Assets
62258000
Annuals > 2 > balance Sheet > property Plant Equipment
6650000
Annuals > 2 > balance Sheet > total Assets
71144000
Annuals > 2 > balance Sheet > payables
677000
Annuals > 2 > balance Sheet > short Term Debt
625000
Annuals > 2 > balance Sheet > long Term Debt
-
Annuals > 2 > balance Sheet > total Liabilities
20839000
Annuals > 2 > balance Sheet > equity
50305000
Annuals > 2 > balance Sheet > currency_symbol
USD
Annuals > 2 > cash Flow > net Income
-83815000
Annuals > 2 > cash Flow > depreciation
1567000
Annuals > 2 > cash Flow > change In Working Capital
-5503000
Annuals > 2 > cash Flow > cash From Operations
-80144000
Annuals > 2 > cash Flow > capital Expenditures
38000
Annuals > 2 > cash Flow > cash From Investing
57008000
Annuals > 2 > cash Flow > cash From Financing
42678000
Annuals > 2 > cash Flow > net Change In Cash
19436000
Annuals > 2 > cash Flow > currency_symbol
USD
Annuals > 2 > ratios > PE
-24.861838301795398
Annuals > 2 > ratios > PB
2.0325899260510885
Annuals > 2 > ratios > ROE
-166.6136566941656
Annuals > 2 > ratios > ROA
-117.81035646013717
Annuals > 2 > ratios > FCF
-80182000
Annuals > 2 > ratios > Piotroski FScore
0
Annuals > 2 > ratios > fcf Percent
-34.42765135251181
Annuals > 2 > health Score
34
Annuals > 3 > quarter
2021-12-31
Annuals > 3 > income Statement > revenue
18739000
Annuals > 3 > income Statement > cost Of Revenue
2001000
Annuals > 3 > income Statement > gross Profit
18739000
Annuals > 3 > income Statement > operating Expenses
84388000
Annuals > 3 > income Statement > operating Income
-65649000
Annuals > 3 > income Statement > interest Expense
-
Annuals > 3 > income Statement > pretax Income
-65660000
Annuals > 3 > income Statement > net Income
-65801000
Annuals > 3 > income Statement > eps
-25.02144662831624
Annuals > 3 > income Statement > dividends Per Share
-
Annuals > 3 > income Statement > shares Outstanding
2629784
Annuals > 3 > income Statement > income Tax Expense
141000
Annuals > 3 > income Statement > EBITDA
-64073000
Annuals > 3 > income Statement > operating Margin
-350.33352900368214
Annuals > 3 > income Statement > total Other Income Expense Net
-11000
Annuals > 3 > income Statement > currency_symbol
USD
Annuals > 3 > balance Sheet > cash
15142000
Annuals > 3 > balance Sheet > short Term Investments
77986000
Annuals > 3 > balance Sheet > receivables
815000
Annuals > 3 > balance Sheet > inventories
-
Annuals > 3 > balance Sheet > total Current Assets
98891000
Annuals > 3 > balance Sheet > property Plant Equipment
8355000
Annuals > 3 > balance Sheet > total Assets
109926000
Annuals > 3 > balance Sheet > payables
3319000
Annuals > 3 > balance Sheet > short Term Debt
436000
Annuals > 3 > balance Sheet > long Term Debt
-
Annuals > 3 > balance Sheet > total Liabilities
25985000
Annuals > 3 > balance Sheet > equity
83941000
Annuals > 3 > balance Sheet > currency_symbol
USD
Annuals > 3 > cash Flow > net Income
-65801000
Annuals > 3 > cash Flow > depreciation
1576000
Annuals > 3 > cash Flow > change In Working Capital
1833000
Annuals > 3 > cash Flow > cash From Operations
-53716000
Annuals > 3 > cash Flow > capital Expenditures
573000
Annuals > 3 > cash Flow > cash From Investing
-22619000
Annuals > 3 > cash Flow > cash From Financing
1393000
Annuals > 3 > cash Flow > net Change In Cash
-74957000
Annuals > 3 > cash Flow > currency_symbol
USD
Annuals > 3 > ratios > PE
-25.02144662831624
Annuals > 3 > ratios > PB
0.9502072732037978
Annuals > 3 > ratios > ROE
-78.38958315960019
Annuals > 3 > ratios > ROA
-59.859359933045866
Annuals > 3 > ratios > FCF
-54289000
Annuals > 3 > ratios > Piotroski FScore
0
Annuals > 3 > ratios > fcf Percent
-2.8971129729441274
Annuals > 3 > health Score
33
Valuation > metrics > PE
-0.18510541797417474
Valuation > metrics > PB
4.41258794225445
Valuation > final Score
35.8741205774555
Valuation > verdict
47.1% Overvalued
Profitability > metrics > ROE
-2.4572621401889694
Profitability > metrics > ROA
-2.216193292165738
Profitability > final Score
15
Profitability > verdict
Weak
Risk > metrics > Debt Equity
0.10877609316633707
Risk > final Score
80
Risk > verdict
Low
Liquidity > metrics > Current Ratio
67.66849939654017
Liquidity > metrics > Quick Ratio
67.66849939654017
Liquidity > final Score
100
Liquidity > verdict
Great
Prev Valuations > 0
35.73337336788269
Prev Valuations > 1
38.49154431777212
Prev Valuations > 2
49.81099630130319
Prev Profitabilities > 0
15
Prev Profitabilities > 1
15
Prev Profitabilities > 2
15
Prev Risks > 0
49
Prev Risks > 1
36
Prev Risks > 2
49
Prev Liquidities > 0
100
Prev Liquidities > 1
100
Prev Liquidities > 2
100
Updated At
2026-01-20T22:39:48.350Z
Earnings History > 0 > period
2025-12-31
Earnings History > 0 > report Date
2026-02-26
Earnings History > 0 > date
2025-12-31
Earnings History > 0 > before After Market
-
Earnings History > 0 > currency
-
Earnings History > 0 > eps Actual
0
Earnings History > 0 > eps Estimate
-0.702
Earnings History > 0 > eps Difference
0.702
Earnings History > 0 > surprise Percent
100
Earnings History > 1 > period
2025-09-30
Earnings History > 1 > report Date
2025-11-04
Earnings History > 1 > date
2025-09-30
Earnings History > 1 > before After Market
-
Earnings History > 1 > currency
-
Earnings History > 1 > eps Actual
-0.15
Earnings History > 1 > eps Estimate
-0.77
Earnings History > 1 > eps Difference
0.62
Earnings History > 1 > surprise Percent
80.5195
Earnings History > 2 > period
2025-06-30
Earnings History > 2 > report Date
2025-08-05
Earnings History > 2 > date
2025-06-30
Earnings History > 2 > before After Market
-
Earnings History > 2 > currency
-
Earnings History > 2 > eps Actual
-0.49
Earnings History > 2 > eps Estimate
-0.7538
Earnings History > 2 > eps Difference
0.2638
Earnings History > 2 > surprise Percent
34.996
Earnings History > 3 > period
2025-03-31
Earnings History > 3 > report Date
2025-05-13
Earnings History > 3 > date
2025-03-31
Earnings History > 3 > before After Market
AfterMarket
Earnings History > 3 > currency
USD
Earnings History > 3 > eps Actual
-0.6
Earnings History > 3 > eps Estimate
-0.84
Earnings History > 3 > eps Difference
0.24
Earnings History > 3 > surprise Percent
28.5714
Earnings History > 4 > period
2024-12-31
Earnings History > 4 > report Date
2025-02-26
Earnings History > 4 > date
2024-12-31
Earnings History > 4 > before After Market
AfterMarket
Earnings History > 4 > currency
USD
Earnings History > 4 > eps Actual
-0.81
Earnings History > 4 > eps Estimate
-0.9443
Earnings History > 4 > eps Difference
0.1343
Earnings History > 4 > surprise Percent
14.2222
Earnings History > 5 > period
2024-09-30
Earnings History > 5 > report Date
2024-11-07
Earnings History > 5 > date
2024-09-30
Earnings History > 5 > before After Market
AfterMarket
Earnings History > 5 > currency
USD
Earnings History > 5 > eps Actual
-1.36
Earnings History > 5 > eps Estimate
-0.82
Earnings History > 5 > eps Difference
-0.54
Earnings History > 5 > surprise Percent
-65.8537
Earnings History > 6 > period
2024-06-30
Earnings History > 6 > report Date
2024-08-07
Earnings History > 6 > date
2024-06-30
Earnings History > 6 > before After Market
AfterMarket
Earnings History > 6 > currency
USD
Earnings History > 6 > eps Actual
-0.86
Earnings History > 6 > eps Estimate
-0.95
Earnings History > 6 > eps Difference
0.09
Earnings History > 6 > surprise Percent
9.4737
Earnings History > 7 > period
2024-03-31
Earnings History > 7 > report Date
2024-05-09
Earnings History > 7 > date
2024-03-31
Earnings History > 7 > before After Market
AfterMarket
Earnings History > 7 > currency
USD
Earnings History > 7 > eps Actual
-1.2
Earnings History > 7 > eps Estimate
-1.17
Earnings History > 7 > eps Difference
-0.03
Earnings History > 7 > surprise Percent
-2.5641
Earnings History > 8 > period
2023-12-31
Earnings History > 8 > report Date
2024-02-29
Earnings History > 8 > date
2023-12-31
Earnings History > 8 > before After Market
AfterMarket
Earnings History > 8 > currency
USD
Earnings History > 8 > eps Actual
-4.05
Earnings History > 8 > eps Estimate
-0.78
Earnings History > 8 > eps Difference
-3.27
Earnings History > 8 > surprise Percent
-419.2308
Earnings History > 9 > period
2023-09-30
Earnings History > 9 > report Date
2023-11-09
Earnings History > 9 > date
2023-09-30
Earnings History > 9 > before After Market
AfterMarket
Earnings History > 9 > currency
USD
Earnings History > 9 > eps Actual
-9.34
Earnings History > 9 > eps Estimate
-0.84
Earnings History > 9 > eps Difference
-8.5
Earnings History > 9 > surprise Percent
-1011.9048
Earnings History > 10 > period
2023-06-30
Earnings History > 10 > report Date
2023-08-11
Earnings History > 10 > date
2023-06-30
Earnings History > 10 > before After Market
-
Earnings History > 10 > currency
USD
Earnings History > 10 > eps Actual
-56.75
Earnings History > 10 > eps Estimate
-3.48
Earnings History > 10 > eps Difference
-53.27
Earnings History > 10 > surprise Percent
-1530.7471
Earnings History > 11 > period
2023-03-31
Earnings History > 11 > report Date
2023-05-11
Earnings History > 11 > date
2023-03-31
Earnings History > 11 > before After Market
-
Earnings History > 11 > currency
USD
Earnings History > 11 > eps Actual
-4.55
Earnings History > 11 > eps Estimate
-0.18
Earnings History > 11 > eps Difference
-4.37
Earnings History > 11 > surprise Percent
-2427.7778
Earnings History > 12 > period
2022-12-31
Earnings History > 12 > report Date
2023-03-02
Earnings History > 12 > date
2022-12-31
Earnings History > 12 > before After Market
-
Earnings History > 12 > currency
USD
Earnings History > 12 > eps Actual
-5
Earnings History > 12 > eps Estimate
-0.2283
Earnings History > 12 > eps Difference
-4.7717
Earnings History > 12 > surprise Percent
-2090.1007
Earnings History > 13 > period
2022-09-30
Earnings History > 13 > report Date
2022-11-03
Earnings History > 13 > date
2022-09-30
Earnings History > 13 > before After Market
-
Earnings History > 13 > currency
USD
Earnings History > 13 > eps Actual
-4.33
Earnings History > 13 > eps Estimate
-0.25
Earnings History > 13 > eps Difference
-4.08
Earnings History > 13 > surprise Percent
-1632
Earnings History > 14 > period
2022-06-30
Earnings History > 14 > report Date
2022-08-04
Earnings History > 14 > date
2022-06-30
Earnings History > 14 > before After Market
-
Earnings History > 14 > currency
USD
Earnings History > 14 > eps Actual
-6.75
Earnings History > 14 > eps Estimate
-0.3178
Earnings History > 14 > eps Difference
-6.4322
Earnings History > 14 > surprise Percent
-2023.9773
Earnings History > 15 > period
2022-03-31
Earnings History > 15 > report Date
2022-05-05
Earnings History > 15 > date
2022-03-31
Earnings History > 15 > before After Market
-
Earnings History > 15 > currency
USD
Earnings History > 15 > eps Actual
-9.25
Earnings History > 15 > eps Estimate
-0.3414
Earnings History > 15 > eps Difference
-8.9086
Earnings History > 15 > surprise Percent
-2609.4318
Earnings History > 16 > period
2021-12-31
Earnings History > 16 > report Date
2022-03-08
Earnings History > 16 > date
2021-12-31
Earnings History > 16 > before After Market
-
Earnings History > 16 > currency
USD
Earnings History > 16 > eps Actual
-7.75
Earnings History > 16 > eps Estimate
-0.2875
Earnings History > 16 > eps Difference
-7.4625
Earnings History > 16 > surprise Percent
-2595.6522
Earnings History > 17 > period
2021-09-30
Earnings History > 17 > report Date
2021-11-04
Earnings History > 17 > date
2021-09-30
Earnings History > 17 > before After Market
-
Earnings History > 17 > currency
USD
Earnings History > 17 > eps Actual
-7.75
Earnings History > 17 > eps Estimate
-0.2792
Earnings History > 17 > eps Difference
-7.4708
Earnings History > 17 > surprise Percent
-2675.788
Earnings History > 18 > period
2021-06-30
Earnings History > 18 > report Date
2021-08-05
Earnings History > 18 > date
2021-06-30
Earnings History > 18 > before After Market
-
Earnings History > 18 > currency
USD
Earnings History > 18 > eps Actual
-2.5
Earnings History > 18 > eps Estimate
-0.1644
Earnings History > 18 > eps Difference
-2.3356
Earnings History > 18 > surprise Percent
-1420.6813
Earnings History > 19 > period
2021-03-31
Earnings History > 19 > report Date
2021-05-10
Earnings History > 19 > date
2021-03-31
Earnings History > 19 > before After Market
-
Earnings History > 19 > currency
USD
Earnings History > 19 > eps Actual
-7
Earnings History > 19 > eps Estimate
-0.2286
Earnings History > 19 > eps Difference
-6.7714
Earnings History > 19 > surprise Percent
-2962.1172
Earnings History > 20 > period
2020-12-31
Earnings History > 20 > report Date
2021-03-18
Earnings History > 20 > date
2020-12-31
Earnings History > 20 > before After Market
-
Earnings History > 20 > currency
USD
Earnings History > 20 > eps Actual
-8.75
Earnings History > 20 > eps Estimate
-0.3429
Earnings History > 20 > eps Difference
-8.4071
Earnings History > 20 > surprise Percent
-2451.7644
Earnings History > 21 > period
2020-09-30
Earnings History > 21 > report Date
2020-11-05
Earnings History > 21 > date
2020-09-30
Earnings History > 21 > before After Market
-
Earnings History > 21 > currency
USD
Earnings History > 21 > eps Actual
-7.25
Earnings History > 21 > eps Estimate
-0.3917
Earnings History > 21 > eps Difference
-6.8583
Earnings History > 21 > surprise Percent
-1750.9063
Earnings History > 22 > period
2020-06-30
Earnings History > 22 > report Date
2020-08-10
Earnings History > 22 > date
2020-06-30
Earnings History > 22 > before After Market
-
Earnings History > 22 > currency
USD
Earnings History > 22 > eps Actual
-10
Earnings History > 22 > eps Estimate
-0.43
Earnings History > 22 > eps Difference
-9.57
Earnings History > 22 > surprise Percent
-2225.5814
Earnings History > 23 > period
2020-03-31
Earnings History > 23 > report Date
2020-05-07
Earnings History > 23 > date
2020-03-31
Earnings History > 23 > before After Market
-
Earnings History > 23 > currency
USD
Earnings History > 23 > eps Actual
-14.25
Earnings History > 23 > eps Estimate
-0.65
Earnings History > 23 > eps Difference
-13.6
Earnings History > 23 > surprise Percent
-2092.3077
Earnings History > 24 > period
2019-12-31
Earnings History > 24 > report Date
2020-02-24
Earnings History > 24 > date
2019-12-31
Earnings History > 24 > before After Market
-
Earnings History > 24 > currency
USD
Earnings History > 24 > eps Actual
-16.25
Earnings History > 24 > eps Estimate
-0.67
Earnings History > 24 > eps Difference
-15.58
Earnings History > 24 > surprise Percent
-2325.3731
Earnings History > 25 > period
2019-09-30
Earnings History > 25 > report Date
2019-11-06
Earnings History > 25 > date
2019-09-30
Earnings History > 25 > before After Market
-
Earnings History > 25 > currency
USD
Earnings History > 25 > eps Actual
-16.5
Earnings History > 25 > eps Estimate
-0.54
Earnings History > 25 > eps Difference
-15.96
Earnings History > 25 > surprise Percent
-2955.5556
Earnings History > 26 > period
2019-06-30
Earnings History > 26 > report Date
2019-08-06
Earnings History > 26 > date
2019-06-30
Earnings History > 26 > before After Market
-
Earnings History > 26 > currency
USD
Earnings History > 26 > eps Actual
-13.75
Earnings History > 26 > eps Estimate
-0.48
Earnings History > 26 > eps Difference
-13.27
Earnings History > 26 > surprise Percent
-2764.5833
Earnings History > 27 > period
2019-03-31
Earnings History > 27 > report Date
2019-05-07
Earnings History > 27 > date
2019-03-31
Earnings History > 27 > before After Market
-
Earnings History > 27 > currency
USD
Earnings History > 27 > eps Actual
-14.75
Earnings History > 27 > eps Estimate
-0.55
Earnings History > 27 > eps Difference
-14.2
Earnings History > 27 > surprise Percent
-2581.8182
Earnings History > 28 > period
2018-12-31
Earnings History > 28 > report Date
2019-03-07
Earnings History > 28 > date
2018-12-31
Earnings History > 28 > before After Market
-
Earnings History > 28 > currency
USD
Earnings History > 28 > eps Actual
-15.5
Earnings History > 28 > eps Estimate
-0.37
Earnings History > 28 > eps Difference
-15.13
Earnings History > 28 > surprise Percent
-4089.1892
Earnings History > 29 > period
2018-09-30
Earnings History > 29 > report Date
2018-11-08
Earnings History > 29 > date
2018-09-30
Earnings History > 29 > before After Market
-
Earnings History > 29 > currency
USD
Earnings History > 29 > eps Actual
-13.5
Earnings History > 29 > eps Estimate
-0.44
Earnings History > 29 > eps Difference
-13.06
Earnings History > 29 > surprise Percent
-2968.1818
Earnings History > 30 > period
2018-06-30
Earnings History > 30 > report Date
2018-08-09
Earnings History > 30 > date
2018-06-30
Earnings History > 30 > before After Market
-
Earnings History > 30 > currency
USD
Earnings History > 30 > eps Actual
-11.5
Earnings History > 30 > eps Estimate
-0.36
Earnings History > 30 > eps Difference
-11.14
Earnings History > 30 > surprise Percent
-3094.4444
Earnings History > 31 > period
2018-03-31
Earnings History > 31 > report Date
2018-05-08
Earnings History > 31 > date
2018-03-31
Earnings History > 31 > before After Market
-
Earnings History > 31 > currency
USD
Earnings History > 31 > eps Actual
-12.25
Earnings History > 31 > eps Estimate
-0.44
Earnings History > 31 > eps Difference
-11.81
Earnings History > 31 > surprise Percent
-2684.0909
Earnings History > 32 > period
2017-12-31
Earnings History > 32 > report Date
2018-03-13
Earnings History > 32 > date
2017-12-31
Earnings History > 32 > before After Market
-
Earnings History > 32 > currency
USD
Earnings History > 32 > eps Actual
-9.75
Earnings History > 32 > eps Estimate
-0.53
Earnings History > 32 > eps Difference
-9.22
Earnings History > 32 > surprise Percent
-1739.6226
Earnings History > 33 > period
2017-09-30
Earnings History > 33 > report Date
2017-11-08
Earnings History > 33 > date
2017-09-30
Earnings History > 33 > before After Market
-
Earnings History > 33 > currency
USD
Earnings History > 33 > eps Actual
-0.48
Earnings History > 33 > eps Estimate
-0.55
Earnings History > 33 > eps Difference
0.07
Earnings History > 33 > surprise Percent
12.7273
Earnings History > 34 > period
2017-06-30
Earnings History > 34 > report Date
2017-08-08
Earnings History > 34 > date
2017-06-30
Earnings History > 34 > before After Market
-
Earnings History > 34 > currency
USD
Earnings History > 34 > eps Actual
-0.47
Earnings History > 34 > eps Estimate
-0.48
Earnings History > 34 > eps Difference
0.01
Earnings History > 34 > surprise Percent
2.0833
Earnings History > 35 > period
2017-03-31
Earnings History > 35 > report Date
2017-05-18
Earnings History > 35 > date
2017-03-31
Earnings History > 35 > before After Market
-
Earnings History > 35 > currency
USD
Earnings History > 35 > eps Actual
-0.47
Earnings History > 35 > eps Estimate
-0.47
Earnings History > 35 > eps Difference
0
Earnings History > 35 > surprise Percent
0
Earnings History > 36 > period
2016-12-31
Earnings History > 36 > report Date
2017-03-08
Earnings History > 36 > date
2016-12-31
Earnings History > 36 > before After Market
-
Earnings History > 36 > currency
USD
Earnings History > 36 > eps Actual
-0.56
Earnings History > 36 > eps Estimate
-0.46
Earnings History > 36 > eps Difference
-0.1
Earnings History > 36 > surprise Percent
-21.7391
Earnings History > 37 > period
2016-09-30
Earnings History > 37 > report Date
2016-11-08
Earnings History > 37 > date
2016-09-30
Earnings History > 37 > before After Market
-
Earnings History > 37 > currency
USD
Earnings History > 37 > eps Actual
-0.47
Earnings History > 37 > eps Estimate
-0.55
Earnings History > 37 > eps Difference
0.08
Earnings History > 37 > surprise Percent
14.5455
Earnings History > 38 > period
2016-06-30
Earnings History > 38 > report Date
2016-08-18
Earnings History > 38 > date
2016-06-30
Earnings History > 38 > before After Market
-
Earnings History > 38 > currency
USD
Earnings History > 38 > eps Actual
-0.46
Earnings History > 38 > eps Estimate
-0.43
Earnings History > 38 > eps Difference
-0.03
Earnings History > 38 > surprise Percent
-6.9767
Earnings History > 39 > period
2016-03-31
Earnings History > 39 > report Date
2016-05-19
Earnings History > 39 > date
2016-03-31
Earnings History > 39 > before After Market
-
Earnings History > 39 > currency
USD
Earnings History > 39 > eps Actual
-8.4758
Earnings History > 39 > eps Estimate
-
Earnings History > 39 > eps Difference
0
Earnings History > 39 > surprise Percent
-
Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD). It develops SPY001, a human monoclonal immunoglobulin G1 antibody designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease). The company is developing SPY002, a human monoclonal antibody (mAb)candidates designed to bind to tumor necrosis factor-like ligand 1A; and SPY120, a combination of SPY001 (anti-a4ß7) and SPY002 (anti-TL1A) antibodies, which are in preclinical studies. In addition, its other early-stage programs include SPY003, an anti-IL-23 mAb; SPY004; SPY130, a combination of anti-a4ß7 and anti-IL-23 mAbs; and SPY230, a combination of anti-TL1A and anti-IL-23 mAbs. The company was formerly known as Aeglea BioTherapeutics, Inc. and changed its name to Spyre Therapeutics, Inc. in November 2023. The company was incorporated in 2013 and is based in Waltham, Massachusetts.
Stock Price
$0.00
increase compared to yesterday.
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Frequency:
Rate:
N/ANext Payout:
N/AWhat momentum indicators show for SYRE stock - 2025 Retail Activity & Real-Time Volume Spike Alerts bollywoodhelpline.com
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How risky is SYRE stock now - July 2025 WrapUp & Smart Allocation Stock Tips bollywoodhelpline.com
Read more →Showing 2 of 10
(Last Updated 2025-09-30)
Rating:
STRONG BUY
Target Price:
$54.2857
Analyst Picks
Strong Buy
10
Buy
0
Hold
1
Sell
0
Strong Sell
0
Sentiment:
Bullish
(Last Updated 2025-09-30)
Health Score
Price to Book Ratio (P/B)
-
Very High
Low ≤ 1
High ≥ 3
Return on Equity (ROE)
-
Very Low
Low ≤ 5%
High ≥ 25%
Return on Assets (ROA)
-
Very Low
Low ≤ 2%
High ≥ 10%
Debt to Equity
-
Very High
Low ≥ 1
High ≤ 0.3
* Institutions hold a combined 0.00% of the total shares of Spyre Therapeutics Inc.
* Investors data is estimated based on stocks listed on Finnton that are currently held by Institution/Fund.
Date
2025-12-31
EPS Estimate
-0.702
Date
2025-09-30
EPS Actual
-0.15
EPS Estimate
-0.77
EPS Difference
0.62
Surprise Percent
80.5195%
(Last Updated 2025-09-30)
(Last Updated 2025-09-30)
Revenue
$ 0
Cost Of Revenue
$ 0
Gross Profit
$ 0
Operating Expenses
$ 0
Operating Income
$ 0
Interest Expense
$ 0
Pretax Income
$ 0
Net Income
$ 0
Income Tax Expense
$ 0
EBITDA
$ 0
Total Other Income Expense Net
$ 0
Earnings Per Share
0
Dividends Per Share
0
Shares Outstanding
0
Operating Margin
0%
(Last Updated 2025-09-30)
Cash
$ 0
Short Term Investments
$ 0
Receivables
$ 0
Inventories
$ 0
Total Current Assets
$ 0
Property Plant Equipment
$ 0
Total Assets
$ 0
Payables
$ 0
Short Term Debt
$ 0
Long Term Debt
$ 0
Total Liabilities
$ 0
Equity
$ 0
(Last Updated 2025-09-30)
Net Income
$ 0
Depreciation
$ 0
Change In Working Capital
$ 0
Cash From Operations
$ 0
Capital Expenditures
$ 0
Cash From Investing
$ 0
Cash From Financing
$ 0
Net Change In Cash
$ 0
Disclaimer: Finnton is a stock screener tool provided for informational and educational purposes only. The data, analysis, and insights offered on this website do not constitute financial, investment, tax, or legal advice. Users are solely responsible for their own investment decisions, and Finnton makes no guarantees regarding the accuracy, completeness, or reliability of the information provided. Past performance is not indicative of future results. Always conduct your own research and consult with a licensed financial advisor before making any investment decisions.